Bioconjugation Chemistry

CreaGen bio-conjugation division provides a comprehensive portfolio of highly specific bio-conjugates to biotech and pharmaceutical companies. Our state-of-the-art laboratories and team of scientists with extensive experience in chemical biology have delivered a number of antibody, protein and nucleic acid based drug conjugates to biotech and pharmaceutical customers.

From novel linker design to conjugation of small molecules, drug substances, fluorescent probes, nucleic acids and peptides, we strive to meet all your conjugation needs and deliver the products in a timely manner with significant cost benefits.  Consider our bio-conjugation chemistry team as your preferred partner in your discovery research.

• Design and development of novel linkers
• Development of conjugate strategy
• Proof of concept through pilot run
• Development of purification and analytical method
• Technology Transfer

CreaGen Advantages:

• Full spectrum of conjugation and labeling services: Design and synthesis of cleavable and non cleavable linkers, small molecules and customers supplied drug compound modifications, fluorescent dyes, non-fluorescent dyes, redox, nanoparticles, and enzymes,
• Flexible technologies: employing solid, solution phase and microwave technologies
• Optimized chemistries: expertise in hundreds of cross linking modifications, activations and conjugations with reactive cross linkers and optimized labeling ratios at client’s request
• Guaranteed quality: all samples are carefully monitored for stability and characterized to ensure batch to batch consistency
• US based services with superior with communications

CreaGen Bioconjugation Services:

We offer personalized solutions for custom conjugation of small molecules such as drugs, metabolites, and labeled compounds with synthetic or natural polymers for specific applications. Our conjugation services include:

• Design and synthesis of novel cleavable and non-cleavable linkers
• Antibody modification and custom conjugation (ADC)
• CDNA antibody conjugates
• Antibody-oligonucleotide conjugates
• PNA-PNA conjugates
• Oligonucleotide-agarose conjugates
• Biomolecule–drug conjugation
• Fluorescent probe custom bioconjugation
• Avidin-biotin system
• Enzyme modifications and bioconjugation
• Polymer surface modification and conjugation (dextran’s)
• Liposome conjugates and derivatives
• Bifunctional chelating agents
• Cross linking peptides
• Cross linking protein
• Reagents: Biotinylation, Iodination, Silane Coupling, Discrete PEG Reagents