CreaGen Cost-Effective Medicinal Chemistry Research Services
For more than 16 years, CreaGen has provided expertise in medicinal chemistry to progress lead molecules to pre-clinical and clinical candidates. Our unusually broad and unconventional expertise in medicinal chemistry has successfully delivered more than 50 preclinical candidates to our partners through more than 100 drug discovery programs.
CreaGen’s cost effective-medicinal chemistry program is an attractive program for all sizes of biotechnology, pharmaceutical companies as well as virtual and start-up companies. For virtual, start-up and biotechnology companies this program provides the opportunity to eliminate the early investment in medicinal chemistry infrastructure. For pharmaceutical companies, this program serves as an extension of their internal capabilities.
Through this business model CreaGen has successfully implemented medicinal chemistry programs with several biotechnology and pharmaceutical companies in the greater Boston area and beyond, and has delivered excellent results to all its partners.
The model includes:
Regular face-to-face meetings with the CreaGen team to discuss the needs of our partner.
An experienced Project Manager from CreaGen.
Immediate assignment of a highly qualified and experienced team of PhD scientists to launch and execute the program.
Fast turnover of projects with aggressive timelines.
Integrated teamwork to produce the target molecules.
Maintenance of excellent communication during the entire collaborative process.
Accurate and confidential record keeping.
Our suite of medicinal chemistry capabilities include:
Automated Parallel library synthesis and purifications
Focused libraries for structure activity relationship (SAR) and structure property relationship (SPR)
Fragment-based hit expansion and evolution
Solving specific med chem issues such as ADME properties, solubility, scaffold-hopping, novelization of leads
Fast follower & back-up candidates
Learn how our synthetic and medicinal chemistry expertise can accelerate your drug discovery research and innovation.
Selected achievements through this program
Taking AMPK target knowledge (no crystal structure), implementing four FTE medicinal chemistry programs and generating an orally bioavailable developmental candidate through scaffold morphing, lead generation and lead optimization iterations in nine months. Participated in due diligence by potential investors. IP was generated.
Taking a 10 micromolar anti-infective lead compound to a sub-nanomolar advanced lead candidate in six months. IP was generated.
Designing 100-membered optimized libraries and delivering two micromolar lead compounds.