Synthetic Chemistry

CreaGen’s newly built 22,000 sq ft laboratory is well equipped with synthetic chemistry equipment and instruments. The laboratories are composed of 15 chemical and 5 bio-safety hoods. Our laboratories are equipped with state of the art automated parallel synthesis and mass directed auto purification systems to support the High Throughput synthesis (HTS) and High Throughput Purification (HTP) of library compounds.

Our customized organic synthesis service model includes

• Route scouting
• Unique & proprietary fragments and discovery platform building blocks
• Synthetic methodology development – validation
• Process development and scale-up synthesis
• Library design and parallel synthesis (solution and solid-phase)
• Chiral separations (analytical and preparative supercritical fluid chromatography)
• Metabolite synthesis
• Controlled substance and high-potency synthesis
• Complex chemistries including polysaccharides and challenging reactions
• Nucleosides and nucleotide synthesis
• Un-natural amino acids, Peptides and Peptide Nucleic Acid synthesis
• Carbohydrates and modified sugars
• Fluorinated and deuterated compounds
• Scale up of lead molecules for GLP-Tox studies
• Non-GMP synthesis.